Diana,
My personal opinion is that you should do this as soon as your monthly volume is enough to justify the "minimum" fee by the merchant bank, which is usually around $25 in fees. So, at a 2.5% rate, that would need to be around $1,000/month in sales.
If you can integrate PayPal and make it flow into your site easily, without causing a lot of checkout hassle, it's a great option to start out with, though.
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